The crash occurred early Wednesday afternoon on Route 33 at Neptune Boulevard in Neptune Township, police said.
Neptune Township police said that Route 33 was closed in both directions between Taylor and Stanley avenues.
One driver was trapped and unresponsive, according to the unconfirmed report, The other driver was suffering a medical episode, that report said at 2 p.m.
NJ DOT was responding for traffic control. "This closure is expected to remain in place for the next several hours," Neptune Township police said on Facebook at about 1 p.m.
Additional details were not immediately available.
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